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10.1007/s00281-016-0567-z

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C5010479!5010479 !27178409
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suck abstract from ncbi

pmid27178409
      Semin+Immunopathol 2016 ; 38 (5 ): 549-61
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  • New insights into basophil heterogeneity #MMPMID27178409
  • Oetjen LK ; Noti M ; Kim BS
  • Semin Immunopathol 2016[Sep]; 38 (5 ): 549-61 PMID27178409 show ga
  • Basophils have become increasingly recognized as important innate immune cells that mediate antihelminth immunity and barrier inflammation. Recent discoveries have uncovered previously unrecognized heterogeneity in basophil populations. However, how diversity in basophil regulation and function impacts human disease remains poorly defined. The goal of the present review is to highlight how new insights into basophil heterogeneity can help us to better understand disease pathogenesis and inform the development of new therapeutics.
  • |Animals [MESH]
  • |Basophils/*cytology/*physiology [MESH]
  • |Bone Marrow Cells/cytology/metabolism [MESH]
  • |Cell Communication/genetics/immunology [MESH]
  • |Cell Differentiation [MESH]
  • |Cytokines/metabolism [MESH]
  • |Disease Susceptibility [MESH]
  • |Extracellular Space/metabolism [MESH]
  • |Hematopoiesis [MESH]
  • |Hematopoietic Stem Cells/cytology/metabolism [MESH]
  • |Humans [MESH]
  • |Immunoglobulin E/immunology/metabolism [MESH]
  • |Interleukin-3/metabolism [MESH]
  • |Intracellular Space/metabolism [MESH]
  • |Signal Transduction [MESH]


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