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10.1016/j.tips.2015.06.005 http://scihub22266oqcxt.onion/10.1016/j.tips.2015.06.005 C4562806!4562806 !26162965     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26162965 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26162965 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Pharmacol+Sci 2015 ; 36 (9 ): 587-95 Nephropedia Template TP {{tp|p=26162965 |t=2015. New immunotherapies targeting the PD-1 pathway |pdf=|usr=}}{{26162965 }} gab.com Text New immunotherapies targeting the PD-1 pathway JO: Trends Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26162965 #FOAvip Ligands from the B7 family bind to receptors of the CD28 family, which regulate early T cell activation in lymphoid organs and control inflammation and autoimmunity in peripheral tissues. Programmed death-1 (PD-1), a member of the CD28 family, is an inhibitory receptor on T cells and is responsible for their dysfunction in infectious diseases and cancers. The complex mechanisms controlling the expression and signaling of PD-1 and programmed death ligand 1 (PD-L1) are emerging. Recently completed and ongoing clinical trials that target these molecules have shown remarkable success by generating durable clinical responses in some cancer patients. In chronic viral infections, preclinical data reveal that targeting PD-1 and its ligands can improve T cell responses and virus clearance. There is also promise in stimulating this pathway for the treatment of autoimmune and inflammatory disorders. Twit Text FOAVip New immunotherapies targeting the PD-1 pathway ????Trends Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26162965 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26162965 #FOAvip English Wikipedia <ref>{{Cite pmid|26162965 }}</ref> New immunotherapies targeting the PD-1 pathway #MMPMID26162965 Chinai JM ; Janakiram M ; Chen F ; Chen W ; Kaplan M ; Zang X Trends Pharmacol Sci 2015[Sep]; 36 (9 ): 587-95 PMID26162965 show ga Ligands from the B7 family bind to receptors of the CD28 family, which regulate early T cell activation in lymphoid organs and control inflammation and autoimmunity in peripheral tissues. Programmed death-1 (PD-1), a member of the CD28 family, is an inhibitory receptor on T cells and is responsible for their dysfunction in infectious diseases and cancers. The complex mechanisms controlling the expression and signaling of PD-1 and programmed death ligand 1 (PD-L1) are emerging. Recently completed and ongoing clinical trials that target these molecules have shown remarkable success by generating durable clinical responses in some cancer patients. In chronic viral infections, preclinical data reveal that targeting PD-1 and its ligands can improve T cell responses and virus clearance. There is also promise in stimulating this pathway for the treatment of autoimmune and inflammatory disorders. |Animals [MESH] |Antibodies, Monoclonal/*immunology/therapeutic use [MESH] |Antineoplastic Agents/*immunology/therapeutic use [MESH] |Antiviral Agents/*immunology/therapeutic use [MESH] |Humans [MESH] |Immunotherapy/*methods [MESH] |Neoplasms/*therapy [MESH] |Programmed Cell Death 1 Receptor/antagonists & inhibitors/*immunology [MESH]New immunotherapies targeting the PD-1 pathway (epmc).pdf DeepDyve Pubget Overpricing