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2016 ; 4
(2
): 37-42
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New drugs in prostate cancer
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Yoo S
; Choi SY
; You D
; Kim CS
Prostate Int
2016[Jun]; 4
(2
): 37-42
PMID27358841
show ga
The standard primary treatment for advanced prostate cancer has been hormonal
therapy since the 1940s. However, prostate cancer inevitably progresses to
castration-resistant prostate cancer (CRPC) after a median duration of 18 months
of androgen deprivation therapy. In patients with CRPC, docetaxel has been
regarded as the standard treatment. However, survival advantages of docetaxel
over other treatments are slim, and the need for new agents persists. In recent
years, novel agents, including abiraterone, enzalutamide, cabazitaxel,
radium-223, and sipuleucel-T, have been approved for the treatment of CRPC, and
more such agents based on diverse mechanisms are under investigation or
evaluation. In this article, the authors reviewed the current literature on
recent advances in medical treatment of prostate cancer, especially CRPC. In
addition, the authors elaborated on novel drugs for prostate cancer currently
undergoing investigation and their mechanisms.