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2016 ; 42
(2
): 146-54
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New anticoagulants for the treatment of venous thromboembolism
#MMPMID27167437
Fernandes CJ
; Alves Júnior JL
; Gavilanes F
; Prada LF
; Morinaga LK
; Souza R
J Bras Pneumol
2016[Apr]; 42
(2
): 146-54
PMID27167437
show ga
Worldwide, venous thromboembolism (VTE) is among the leading causes of death from
cardiovascular disease, surpassed only by acute myocardial infarction and stroke.
The spectrum of VTE presentations ranges, by degree of severity, from deep vein
thrombosis to acute pulmonary thromboembolism. Treatment is based on full
anticoagulation of the patients. For many decades, it has been known that
anticoagulation directly affects the mortality associated with VTE. Until the
beginning of this century, anticoagulant therapy was based on the use of
unfractionated or low-molecular-weight heparin and vitamin K antagonists,
warfarin in particular. Over the past decades, new classes of anticoagulants have
been developed, such as factor Xa inhibitors and direct thrombin inhibitors,
which significantly changed the therapeutic arsenal against VTE, due to their
efficacy and safety when compared with the conventional treatment. The focus of
this review was on evaluating the role of these new anticoagulants in this
clinical context.