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pmid29906789
      Top+Antivir+Med 2018 ; 26 (2 ): 58-61
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  • New and Noteworthy in Tuberculosis Diagnostics and Treatment #MMPMID29906789
  • Swindells S
  • Top Antivir Med 2018[Jun]; 26 (2 ): 58-61 PMID29906789 show ga
  • People with HIV infection with latent tuberculosis (TB) infection (LTBI) are at a 10-fold greater risk of developing active disease. Interferon gamma release assays and tuberculin skin testing have approximately 65% to 70% specificity for diagnosing LTBI in HIV-infected patients. LTBI can be successfully treated with isoniazid preventive therapy and early antiretroviral therapy (ART). Rapid molecular diagnostics have approximately 88% sensitivity and 98% specificity for identifying active TB. ART should be started early in patients with TB. A number of ART regimens are recommended in co-treatment that minimize the risk of drug-drug interactions. Although progress has been made, better diagnostics and TB regimens with lower risks of drug-drug interactions and shorter treatment durations are still needed. This article summarizes a presentation by Susan Swindells, MBBS, at the Ryan White HIV/AIDS Program Clinical Care Conference held in San Antonio in August 2017.
  • |Adult [MESH]
  • |Antitubercular Agents/*therapeutic use [MESH]
  • |Female [MESH]
  • |HIV Infections/drug therapy [MESH]
  • |Humans [MESH]
  • |Isoniazid/*therapeutic use [MESH]
  • |Latent Tuberculosis/*diagnosis [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Sensitivity and Specificity [MESH]
  • |Tuberculin Test [MESH]


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