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2017 ; 13
(1
): 22-31
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New Therapies for Hepatitis C Virus Infection
#MMPMID28420944
Horsley-Silva JL
; Vargas HE
Gastroenterol Hepatol (N Y)
2017[Jan]; 13
(1
): 22-31
PMID28420944
show ga
Approximately 350 million people worldwide are infected with hepatitis C virus
(HCV), which is associated with morbidity and mortality related to cirrhosis,
hepatocellular carcinoma, or liver failure. Recently, vast improvements have been
made with the development of direct-acting antiviral (DAA) agents, which are
all-oral, are better tolerated than interferon-based treatment, and provide a
sustained virologic response in more than 90% of treated patients. This article
reviews the new therapies available for HCV infection, with a focus on patients
who have chronic HCV with and without compensated cirrhosis. As DAA development
continues, more attention will need to be given to special patient populations,
specifically to patients who fail treatment due to emerging resistant strains.
Considerable challenges yet to be overcome are incremental diagnosis of
unidentified patients and linkage to care that is affordable and available to all
patients.