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2015 ; 2015
(ä): 875961
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New Insights for Oxidative Stress and Diabetes Mellitus
#MMPMID26064426
Maiese K
Oxid Med Cell Longev
2015[]; 2015
(ä): 875961
PMID26064426
show ga
The release of reactive oxygen species (ROS) and the generation of oxidative
stress are considered critical factors for the pathogenesis of diabetes mellitus
(DM), a disorder that is growing in prevalence and results in significant
economic loss. New therapeutic directions that address the detrimental effects of
oxidative stress may be especially warranted to develop effective care for the
millions of individuals that currently suffer from DM. The mechanistic target of
rapamycin (mTOR), silent mating type information regulation 2 homolog 1 (S.
cerevisiae) (SIRT1), and Wnt1 inducible signaling pathway protein 1 (WISP1) are
especially justified to be considered treatment targets for DM since these
pathways can address the complex relationship between stem cells, trophic
factors, impaired glucose tolerance, programmed cell death pathways of apoptosis
and autophagy, tissue remodeling, cellular energy homeostasis, and vascular
biology that greatly impact the biology and disease progression of DM. The
translation and development of these pathways into viable therapies will require
detailed understanding of their proliferative nature to maximize clinical
efficacy and limit adverse effects that have the potential to lead to unintended
consequences.
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