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2016 ; 6
(ä): 25280
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New Hosts of The Lassa Virus
#MMPMID27140942
Olayemi A
; Cadar D
; Magassouba N
; Obadare A
; Kourouma F
; Oyeyiola A
; Fasogbon S
; Igbokwe J
; Rieger T
; Bockholt S
; Jérôme H
; Schmidt-Chanasit J
; Garigliany M
; Lorenzen S
; Igbahenah F
; Fichet JN
; Ortsega D
; Omilabu S
; Günther S
; Fichet-Calvet E
Sci Rep
2016[May]; 6
(ä): 25280
PMID27140942
show ga
Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several
thousand people in West Africa annually. For 40 years, the Natal multimammate
rat, Mastomys natalensis, has been assumed to be the sole host of LASV. We found
evidence that LASV is also hosted by other rodent species: the African wood mouse
Hylomyscus pamfi in Nigeria, and the Guinea multimammate mouse Mastomys
erythroleucus in both Nigeria and Guinea. Virus strains from these animals were
isolated in the BSL-4 laboratory and fully sequenced. Phylogenetic analyses of
viral genes coding for glycoprotein, nucleoprotein, polymerase and matrix protein
show that Lassa strains detected in M. erythroleucus belong to lineages III and
IV. The strain from H. pamfi clusters close to lineage I (for S gene) and between
II &III (for L gene). Discovery of new rodent hosts has implications for LASV
evolution and its spread into new areas within West Africa.