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10.1038/srep25280

http://scihub22266oqcxt.onion/10.1038/srep25280
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C4853722!4853722 !27140942
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suck abstract from ncbi


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pmid27140942
      Sci+Rep 2016 ; 6 (ä): 25280
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  • New Hosts of The Lassa Virus #MMPMID27140942
  • Olayemi A ; Cadar D ; Magassouba N ; Obadare A ; Kourouma F ; Oyeyiola A ; Fasogbon S ; Igbokwe J ; Rieger T ; Bockholt S ; Jérôme H ; Schmidt-Chanasit J ; Garigliany M ; Lorenzen S ; Igbahenah F ; Fichet JN ; Ortsega D ; Omilabu S ; Günther S ; Fichet-Calvet E
  • Sci Rep 2016[May]; 6 (ä): 25280 PMID27140942 show ga
  • Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis, has been assumed to be the sole host of LASV. We found evidence that LASV is also hosted by other rodent species: the African wood mouse Hylomyscus pamfi in Nigeria, and the Guinea multimammate mouse Mastomys erythroleucus in both Nigeria and Guinea. Virus strains from these animals were isolated in the BSL-4 laboratory and fully sequenced. Phylogenetic analyses of viral genes coding for glycoprotein, nucleoprotein, polymerase and matrix protein show that Lassa strains detected in M. erythroleucus belong to lineages III and IV. The strain from H. pamfi clusters close to lineage I (for S gene) and between II &III (for L gene). Discovery of new rodent hosts has implications for LASV evolution and its spread into new areas within West Africa.
  • |*Host Specificity [MESH]
  • |Africa [MESH]
  • |Animals [MESH]
  • |Genotype [MESH]
  • |Guinea [MESH]
  • |Lassa virus/classification/genetics/*isolation & purification/*physiology [MESH]
  • |Murinae/*virology [MESH]
  • |Nigeria [MESH]
  • |Phylogeny [MESH]


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