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2017 ; 8
(ä): 1349
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Neutrophils in Gliomas
#MMPMID29123517
Massara M
; Persico P
; Bonavita O
; Mollica Poeta V
; Locati M
; Simonelli M
; Bonecchi R
Front Immunol
2017[]; 8
(ä): 1349
PMID29123517
show ga
Neutrophils are the most abundant white blood cells and are the first recruited
to inflammatory sites. Neutrophils are an important component of the tumor stroma
and can exert both anti-tumoral and pro-tumoral activities, depending on their
maturation and activation state. In human gliomas, the number of circulating and
infiltrating neutrophils correlates with the severity of the disease, indicating
a prognostic and possible pro-tumoral role for these leukocytes. In glioma
preclinical models, neutrophils promote tumor growth and orchestrate the
resistance to anti-angiogenic therapies. Nevertheless, recent data indicate that
neutrophils can be activated to directly kill tumor cells or to orchestrate the
anti-tumoral response. Here, we review current knowledge about the role of
neutrophils in glioma and their possible involvement in new strategies to improve
current cancer therapies.