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10.3389/fimmu.2017.01349

http://scihub22266oqcxt.onion/10.3389/fimmu.2017.01349
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suck abstract from ncbi


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pmid29123517
      Front+Immunol 2017 ; 8 (ä): 1349
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  • Neutrophils in Gliomas #MMPMID29123517
  • Massara M ; Persico P ; Bonavita O ; Mollica Poeta V ; Locati M ; Simonelli M ; Bonecchi R
  • Front Immunol 2017[]; 8 (ä): 1349 PMID29123517 show ga
  • Neutrophils are the most abundant white blood cells and are the first recruited to inflammatory sites. Neutrophils are an important component of the tumor stroma and can exert both anti-tumoral and pro-tumoral activities, depending on their maturation and activation state. In human gliomas, the number of circulating and infiltrating neutrophils correlates with the severity of the disease, indicating a prognostic and possible pro-tumoral role for these leukocytes. In glioma preclinical models, neutrophils promote tumor growth and orchestrate the resistance to anti-angiogenic therapies. Nevertheless, recent data indicate that neutrophils can be activated to directly kill tumor cells or to orchestrate the anti-tumoral response. Here, we review current knowledge about the role of neutrophils in glioma and their possible involvement in new strategies to improve current cancer therapies.
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