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2017 ; 4
(3
): 329-337
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Neutrophils as Components of Mucosal Homeostasis
#MMPMID28884136
Hall CHT
; Campbell EL
; Colgan SP
Cell Mol Gastroenterol Hepatol
2017[Nov]; 4
(3
): 329-337
PMID28884136
show ga
Inflammatory responses in the intestinal mucosa inevitably result in the
recruitment of neutrophils (polymorphonuclear leukocytes [PMNs]). Epithelial
cells that line the mucosa play an integral role in the recruitment, maintenance,
and clearance of PMNs at sites of inflammation. The consequences of such
PMN-epithelial interactions often determine tissue responses and, ultimately,
organ function. For this reason, there is significant interest in understanding
how PMNs function in the mucosa during inflammation. Recent studies have shown
that PMNs play a more significant role in molding of the immune response than
previously thought. Here, we review the recent literature regarding the
contribution of PMNs to the development and resolution of inflammation, with an
emphasis on the role of the tissue microenvironment and pathways for promoting
epithelial restitution. These studies highlight the complex nature of
inflammatory pathways and provide important insight into the difficulties of
treating mucosal inflammation.