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2014 ; 39
(1
): 116-21
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Neutrophil extracellular traps in physiology and pathology
#MMPMID26155111
Manda A
; Pruchniak MP
; Ara?na M
; Demkow UA
Cent Eur J Immunol
2014[]; 39
(1
): 116-21
PMID26155111
show ga
Neutrophil extracellular traps (NETs) are developed by nature to protect the body
from furious invaders. On the other hand NET s can play an important role in
human pathology. Recent studies have shown that neutrophils are able to perform
beneficial suicide to create an unique microbicidal net composed from cellular
content attached to chromatic frame. It is a powerful tool that primary serve as
protector from severe infections, but this weapon is also a double ended sword of
the immunity. If overproduced NET s provoke certain autoimmune diseases,
coagulation disorders and even cancer metastases. Moreover, due to the
competition between host and pathogens, the microorganism have developed a width
repertoire of sophisticated evading mechanisms, like creation of polysaccharide
capsule or changes in cell wall charge. Therefore it is important to increase the
knowledge about paths underlying NET s formation and degradation processes if we
want to efficiently fight with bacterial infections and certain diseases.