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10.1189/jlb.3HI1014-493R http://scihub22266oqcxt.onion/10.1189/jlb.3HI1014-493R C4763951!4763951 !25743626     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25743626 &cmd=llinks): Failed to open stream: HTTP request failed! 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Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis |pdf=|usr=}}{{25743626 }} gab.com Text Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis JO: J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=25743626 #FOAvip IPF is a progressive lung disorder characterized by fibroblast proliferation and myofibroblast differentiation. Although neutrophil accumulation within IPF lungs has been negatively correlated with outcomes, the role played by neutrophils in lung fibrosis remains poorly understood. We have demonstrated previously that NE promotes lung cancer cell proliferation and hypothesized that it may have a similar effect on fibroblasts. In the current study, we show that NE(-/-) mice are protected from asbestos-induced lung fibrosis. NE(-/-) mice displayed reduced fibroblast and myofibroblast content when compared with controls. NE directly both lung fibroblast proliferation and myofibroblast differentiation in vitro, as evidenced by proliferation assays, collagen gel contractility assays, and ?SMA induction. Furthermore, ?SMA induction occurs in a TGF-?-independent fashion. Treatment of asbestos-recipient mice with ONO-5046, a synthetic NE antagonist, reduced hydroxyproline content. Thus, the current study points to a key role for neutrophils and NE in the progression of lung fibrosis. Lastly, the study lends rationale to use of NE-inhibitory approaches as a novel therapeutic strategy for patients with lung fibrosis. Twit Text FOAVip Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis ????J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=25743626 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25743626 #FOAvip English Wikipedia <ref>{{Cite pmid|25743626 }}</ref> Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis #MMPMID25743626 Gregory AD ; Kliment CR ; Metz HE ; Kim KH ; Kargl J ; Agostini BA ; Crum LT ; Oczypok EA ; Oury TA ; Houghton AM J Leukoc Biol 2015[Aug]; 98 (2 ): 143-52 PMID25743626 show ga IPF is a progressive lung disorder characterized by fibroblast proliferation and myofibroblast differentiation. Although neutrophil accumulation within IPF lungs has been negatively correlated with outcomes, the role played by neutrophils in lung fibrosis remains poorly understood. We have demonstrated previously that NE promotes lung cancer cell proliferation and hypothesized that it may have a similar effect on fibroblasts. In the current study, we show that NE(-/-) mice are protected from asbestos-induced lung fibrosis. NE(-/-) mice displayed reduced fibroblast and myofibroblast content when compared with controls. NE directly both lung fibroblast proliferation and myofibroblast differentiation in vitro, as evidenced by proliferation assays, collagen gel contractility assays, and ?SMA induction. Furthermore, ?SMA induction occurs in a TGF-?-independent fashion. Treatment of asbestos-recipient mice with ONO-5046, a synthetic NE antagonist, reduced hydroxyproline content. Thus, the current study points to a key role for neutrophils and NE in the progression of lung fibrosis. Lastly, the study lends rationale to use of NE-inhibitory approaches as a novel therapeutic strategy for patients with lung fibrosis. |Animals [MESH] |Cell Differentiation [MESH] |Cell Proliferation [MESH] |Disease Models, Animal [MESH] |Gene Expression Regulation [MESH] |Humans [MESH] |Insulin Receptor Substrate Proteins/genetics/immunology [MESH] |Leukocyte Elastase/genetics/immunology/*metabolism [MESH] |Lung/*enzymology/immunology/pathology [MESH] |Mice [MESH] |Myofibroblasts/*enzymology/immunology/pathology [MESH] |Neutrophils/*enzymology/immunology/pathology [MESH] |Phosphatidylinositol 3-Kinases/genetics/immunology [MESH] |Proto-Oncogene Proteins c-akt/genetics/immunology [MESH] |Pulmonary Emphysema/*enzymology/genetics/immunology/pathology [MESH] |Pulmonary Fibrosis/*enzymology/genetics/immunology/pathology [MESH]Neutrophil elastase promotes myofibroblast differentiation in lung fib(epmc).pdf DeepDyve Pubget Overpricing