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10.1107/S2052252516013439 http://scihub22266oqcxt.onion/10.1107/S2052252516013439 C5391850!5391850 !28461889     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28461889 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       IUCrJ 2016 ; 3 (Pt 5 ): 296-297 Nephropedia Template TP {{tp|p=28461889 |t=2016. Neutron crystallography aids in drug design |pdf=|usr=}}{{28461889 }} gab.com Text Neutron crystallography aids in drug design JO: IUCrJ http://www.kidney.de/pget.php?&tw=1&pmid=28461889 #FOAvip Since drugs bind to their targets through directional H bonding and non-directional hydrophobic and electrostatic interactions, neutron crystallography can help guide structure-based drug design. This is illustrated by McKenna and co-workers [Aggarwal et al. (2016), IUCrJ, 3, 319-325] who describe the room-temperature neutron structure of human carbonic anyhydrase II in complex with the clinical inhibitor methazolamide to 2.2?Å resolution, and compare this with the previously determined room-temperature neutron structure of human carbonic anyhydrase II in complex with the clinical inhibitor acetazolamide to 2.0?Å resolution [Fisher et al. (2012). J. Am. Chem. Soc.134, 14726-14729]. Twit Text FOAVip Neutron crystallography aids in drug design ????IUCrJ http://www.kidney.de/pget.php?&tw=1&pmid=28461889 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28461889 #FOAvip English Wikipedia <ref>{{Cite pmid|28461889 }}</ref> Neutron crystallography aids in drug design #MMPMID28461889 Blakeley MP IUCrJ 2016[Sep]; 3 (Pt 5 ): 296-297 PMID28461889 show ga Since drugs bind to their targets through directional H bonding and non-directional hydrophobic and electrostatic interactions, neutron crystallography can help guide structure-based drug design. This is illustrated by McKenna and co-workers [Aggarwal et al. (2016), IUCrJ, 3, 319-325] who describe the room-temperature neutron structure of human carbonic anyhydrase II in complex with the clinical inhibitor methazolamide to 2.2?Å resolution, and compare this with the previously determined room-temperature neutron structure of human carbonic anyhydrase II in complex with the clinical inhibitor acetazolamide to 2.0?Å resolution [Fisher et al. (2012). J. Am. Chem. Soc.134, 14726-14729]. äNeutron crystallography aids in drug design (epmc).pdf DeepDyve Pubget Overpricing