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10.1172/jci.insight.99171 http://scihub22266oqcxt.onion/10.1172/jci.insight.99171 C5926911!5926911 !29563343     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29563343 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29563343 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       JCI+Insight 2018 ; 3 (6 ): ä Nephropedia Template TP {{tp|p=29563343 |t=2018. Neuropathic pain in a Fabry disease rat model |pdf=|usr=}}{{29563343 }} gab.com Text Neuropathic pain in a Fabry disease rat model JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=29563343 #FOAvip Fabry disease, the most common lysosomal storage disease, affects multiple organs and results in a shortened life span. This disease is caused by a deficiency of the lysosomal enzyme ?-galactosidase A, which leads to glycosphingolipid accumulation in many cell types. Neuropathic pain is an early and severely debilitating symptom in patients with Fabry disease, but the cellular and molecular mechanisms that cause the pain are unknown. We generated a rat model of Fabry disease, the first nonmouse model to our knowledge. Fabry rats had substantial serum and tissue accumulation of ?-galactosyl glycosphingolipids and had pronounced mechanical pain behavior. Additionally, Fabry rat dorsal root ganglia displayed global N-glycan alterations, sensory neurons were laden with inclusions, and sensory neuron somata exhibited prominent sensitization to mechanical force. We found that the cation channel transient receptor potential ankyrin 1 (TRPA1) is sensitized in Fabry rat sensory neurons and that TRPA1 antagonism reversed the behavioral mechanical sensitization. This study points toward TRPA1 as a potentially novel target to treat the pain experienced by patients with Fabry disease. Twit Text FOAVip Neuropathic pain in a Fabry disease rat model ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=29563343 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29563343 #FOAvip English Wikipedia <ref>{{Cite pmid|29563343 }}</ref> Neuropathic pain in a Fabry disease rat model #MMPMID29563343 Miller JJ ; Aoki K ; Moehring F ; Murphy CA ; O'Hara CL ; Tiemeyer M ; Stucky CL ; Dahms NM JCI Insight 2018[Mar]; 3 (6 ): ä PMID29563343 show ga Fabry disease, the most common lysosomal storage disease, affects multiple organs and results in a shortened life span. This disease is caused by a deficiency of the lysosomal enzyme ?-galactosidase A, which leads to glycosphingolipid accumulation in many cell types. Neuropathic pain is an early and severely debilitating symptom in patients with Fabry disease, but the cellular and molecular mechanisms that cause the pain are unknown. We generated a rat model of Fabry disease, the first nonmouse model to our knowledge. Fabry rats had substantial serum and tissue accumulation of ?-galactosyl glycosphingolipids and had pronounced mechanical pain behavior. Additionally, Fabry rat dorsal root ganglia displayed global N-glycan alterations, sensory neurons were laden with inclusions, and sensory neuron somata exhibited prominent sensitization to mechanical force. We found that the cation channel transient receptor potential ankyrin 1 (TRPA1) is sensitized in Fabry rat sensory neurons and that TRPA1 antagonism reversed the behavioral mechanical sensitization. This study points toward TRPA1 as a potentially novel target to treat the pain experienced by patients with Fabry disease. |Animals [MESH] |Animals, Genetically Modified [MESH] |Behavior, Animal [MESH] |Disease Models, Animal [MESH] |Electrophysiology [MESH] |Fabry Disease/*complications/*metabolism [MESH] |Female [MESH] |Ganglia, Spinal/metabolism/pathology [MESH] |Gene Knockdown Techniques [MESH] |Genetic Predisposition to Disease/genetics [MESH] |Glycosphingolipids/blood/metabolism [MESH] |Humans [MESH] |Liver [MESH] |Male [MESH] |Neuralgia/*complications/*metabolism [MESH] |Rats [MESH] |Sensory Receptor Cells/metabolism/pathology [MESH] |TRPA1 Cation Channel/metabolism [MESH]Neuropathic pain in a Fabry disease rat model (epmc).pdf DeepDyve Pubget Overpricing