Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24907657
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Opin+Neurobiol
2014 ; 29
(ä): 48-56
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Neuromodulation of neurons and synapses
#MMPMID24907657
Nadim F
; Bucher D
Curr Opin Neurobiol
2014[Dec]; 29
(ä): 48-56
PMID24907657
show ga
Neuromodulation underlies the flexibility of neural circuit operation and
behavior. Individual neuromodulators can have divergent actions in a neuron by
targeting multiple physiological mechanisms. Conversely, multiple neuromodulators
may have convergent actions through overlapping targets. The divergent and
convergent neuromodulator actions can be unambiguously synergistic or
antagonistic, but neuromodulation often entails balanced adjustment of nonlinear
membrane and synaptic properties by targeting ion channel and synaptic dynamics
rather than just excitability or synaptic strength. In addition, neuromodulators
can exert effects at multiple timescales, from short-term adjustments of neuron
and synapse function to persistent long-term regulation. This short review
summarizes some highlights of the diverse actions of neuromodulators on ion
channel and synaptic properties.