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2018 ; 56
(2
): 99-105
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Neurological manifestations of primary Sjögren s syndrome
#MMPMID29853725
Perzy?ska-Mazan J
; Ma?li?ska M
; Gasik R
Reumatologia
2018[]; 56
(2
): 99-105
PMID29853725
show ga
Primary Sjögren's syndrome (pSS) is an autoimmune connective tissue disease
affecting the exocrine glands, leading to damage of their structure and
impairment of their function. In the course of pSS the internal organs may be
involved and the symptoms may concern any system. Neurological disorders are one
of the most common extraglandular manifestations of pSS. Available literature
data estimate the prevalence of neurological symptoms as about 8.5-70% of
patients diagnosed with pSS. The most common neurological complication of pSS is
peripheral neuropathy, and in particular sensory polyneuropathy. Central nervous
system involvement is much less common. There are also reports of various
symptoms connected with damage to cranial nerves and the autonomic nervous
system. A careful neurological evaluation, combined with neurophysiological
tests, is recommended in patients with pSS. This review summarizes the
neurological manifestations of pSS, their possible pathogenic mechanisms,
diagnostic evaluation and potential treatment.