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10.1146/annurev-neuro-071714-034019 http://scihub22266oqcxt.onion/10.1146/annurev-neuro-071714-034019 C4809143!4809143 !25840006     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25840006 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25840006 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Annu+Rev+Neurosci 2015 ; 38 (ä): 105-25 Nephropedia Template TP {{tp|p=25840006 |t=2015. Neurological aspects of human glycosylation disorders |pdf=|usr=}}{{25840006 }} gab.com Text Neurological aspects of human glycosylation disorders JO: Annu Rev Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25840006 #FOAvip This review presents principles of glycosylation, describes the relevant glycosylation pathways and their related disorders, and highlights some of the neurological aspects and issues that continue to challenge researchers. More than 100 rare human genetic disorders that result from deficiencies in the different glycosylation pathways are known today. Most of these disorders impact the central and/or peripheral nervous systems. Patients typically have developmental delays/intellectual disabilities, hypotonia, seizures, neuropathy, and metabolic abnormalities in multiple organ systems. Among these disorders there is great clinical diversity because all cell types differentially glycosylate proteins and lipids. The patients have hundreds of misglycosylated products, which afflict a myriad of processes, including cell signaling, cell-cell interaction, and cell migration. This vast complexity in glycan composition and function, along with the limited availability of analytic tools, has impeded the identification of key glycosylated molecules that cause pathologies. To date, few critical target proteins have been pinpointed. Twit Text FOAVip Neurological aspects of human glycosylation disorders ????Annu Rev Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25840006 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25840006 #FOAvip English Wikipedia <ref>{{Cite pmid|25840006 }}</ref> Neurological aspects of human glycosylation disorders #MMPMID25840006 Freeze HH ; Eklund EA ; Ng BG ; Patterson MC Annu Rev Neurosci 2015[Jul]; 38 (ä): 105-25 PMID25840006 show ga This review presents principles of glycosylation, describes the relevant glycosylation pathways and their related disorders, and highlights some of the neurological aspects and issues that continue to challenge researchers. More than 100 rare human genetic disorders that result from deficiencies in the different glycosylation pathways are known today. Most of these disorders impact the central and/or peripheral nervous systems. Patients typically have developmental delays/intellectual disabilities, hypotonia, seizures, neuropathy, and metabolic abnormalities in multiple organ systems. Among these disorders there is great clinical diversity because all cell types differentially glycosylate proteins and lipids. The patients have hundreds of misglycosylated products, which afflict a myriad of processes, including cell signaling, cell-cell interaction, and cell migration. This vast complexity in glycan composition and function, along with the limited availability of analytic tools, has impeded the identification of key glycosylated molecules that cause pathologies. To date, few critical target proteins have been pinpointed. |Animals [MESH] |Autistic Disorder/complications/*metabolism [MESH] |Biomarkers/metabolism [MESH] |Congenital Disorders of Glycosylation/*complications/*metabolism [MESH] |Epilepsy/complications/*metabolism [MESH] |Eye Diseases/complications/*metabolism [MESH] |Glycosaminoglycans/metabolism [MESH] |Glycosylation [MESH] |Humans [MESH] |Intellectual Disability/complications/*metabolism [MESH]Neurological aspects of human glycosylation disorders (epmc).pdf DeepDyve Pubget Overpricing