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2015 ; 12
(12
): 926-36
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Neurological Effects of Bisphenol A and its Analogues
#MMPMID26664253
Inadera H
Int J Med Sci
2015[]; 12
(12
): 926-36
PMID26664253
show ga
The endocrine disrupting chemical bisphenol A (BPA) is widely used in the
production of polycarbonate plastics and epoxy resins. The use of BPA-containing
products in daily life makes exposure ubiquitous, and the potential human health
risks of this chemical are a major public health concern. Although numerous in
vitro and in vivo studies have been published on the effects of BPA on biological
systems, there is controversy as to whether ordinary levels of exposure can have
adverse effects in humans. However, the increasing incidence of developmental
disorders is of concern, and accumulating evidence indicates that BPA has
detrimental effects on neurological development. Other bisphenol analogues, used
as substitutes for BPA, are also suspected of having a broad range of biological
actions. The objective of this review is to summarize our current understanding
of the neurobiological effects of BPA and its analogues, and to discuss
preventive strategies from a public health perspective.
|Animals
[MESH]
|Benzhydryl Compounds/*toxicity/urine
[MESH]
|Environmental Exposure/analysis
[MESH]
|Environmental Monitoring
[MESH]
|Female
[MESH]
|Hazardous Substances/toxicity/urine
[MESH]
|Humans
[MESH]
|Male
[MESH]
|Nervous System/*drug effects/*growth & development
[MESH]
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