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2005 ; 16
(1
): 9-13
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Neuroleptic malignant syndrome: diagnostic and therapeutic dilemmas
#MMPMID16082075
Fekadu A
; Bisson JI
Behav Neurol
2005[]; 16
(1
): 9-13
PMID16082075
show ga
Neuroleptic malignant syndrome (NMS) is a life threatening medical state
complicating the use of antipsychotic medications and other drugs that affect the
dopaminergic system on administration or withdrawal. The condition was recognised
nearly half a century ago, shortly after the discovery of antipsychotic
medications. However, there are still no systematic studies about NMS. There are
no definitive guidelines on its treatment. Although early recognition is
emphasised and usually possible, delayed diagnosis is not rare. We here report on
a case of NMS complicated by renal failure, and possibly respiratory failure. The
report underscores the seriousness of delayed diagnosis and puts forward a
comprehensive management recommendation based on our experience and the existing
literature.