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10.1097/COH.0000000000000112

http://scihub22266oqcxt.onion/10.1097/COH.0000000000000112
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C4217490!4217490!25250553
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suck abstract from ncbi


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pmid25250553      Curr+Opin+HIV+AIDS 2014 ; 9 (6): 545-51
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  • Neuroimaging of HIV Associated Neurocognitive Disorders (HAND) #MMPMID25250553
  • Ances BM; Hammoud DA
  • Curr Opin HIV AIDS 2014[Nov]; 9 (6): 545-51 PMID25250553show ga
  • Purpose of review: HIV enters the brain after initial infection, and with time can lead to HIV associated neurocognitive disorders (HAND). While the introduction of combination antiretroviral therapy (cART) has reduced the more severe forms of HAND, milder forms are still highly prevalent. The ?gold standard? for HAND diagnosis remains detailed neuropsychological performance (NP) testing but additional biomarkers (including neuroimaging) may assist in early detection of HAND. Recent findings: We review the application of recently developed non-invasive magnetic resonance imaging (MRI) and positron emission tomography (PET) techniques in HIV+ individuals. In particular, magnetic resonance spectroscopy (MRS) may be more sensitive than conventional MRI alone in detecting HIV associated changes. Diffusion tensor imaging (DTI) has become increasingly popular for assessing changes in white matter structural integrity due to HIV. Both functional MRI and PET have been limitedly performed but could provide keys for characterizing neuropathophysiologic changes due to HIV. Summary: It is hoped that continued progress will allow novel neuroimaging methods to be included in future HAND management guidelines.
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