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2016 ; 7
(ä): 10838
Nephropedia Template TP
Epp JR
; Silva Mera R
; Köhler S
; Josselyn SA
; Frankland PW
Nat Commun
2016[Feb]; 7
(ä): 10838
PMID26917323
show ga
Established memories may interfere with the encoding of new memories,
particularly when existing and new memories overlap in content. By manipulating
levels of hippocampal neurogenesis, here we show that neurogenesis regulates this
form of proactive interference. Increasing hippocampal neurogenesis weakens
existing memories and, in doing so, facilitates the encoding of new, conflicting
(but not non-conflicting) information in mice. Conversely, decreasing
neurogenesis stabilizes existing memories, and impedes the encoding of new,
conflicting information. These results suggest that reduced proactive
interference is an adaptive benefit of neurogenesis-induced forgetting.