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2018 ; 9
(ä): 1440
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Neuroendocrine Control of Macrophage Development and Function
#MMPMID29988513
Jurberg AD
; Cotta-de-Almeida V
; Temerozo JR
; Savino W
; Bou-Habib DC
; Riederer I
Front Immunol
2018[]; 9
(ä): 1440
PMID29988513
show ga
Macrophages carry out numerous physiological activities that are essential for
both systemic and local homeostasis, as well as innate and adaptive immune
responses. Their biology is intricately regulated by hormones, neuropeptides, and
neurotransmitters, establishing distinct neuroendocrine axes. The control is
pleiotropic, including maturation of bone marrow-derived myeloid precursors, cell
differentiation into functional subpopulations, cytotoxic activity, phagocytosis,
production of inflammatory mediators, antigen presentation, and activation of
effector lymphocytes. Additionally, neuroendocrine components modulate macrophage
ability to influence tumor growth and to prevent the spreading of infective
agents. Interestingly, macrophage-derived factors enhance glucocorticoid
production through the stimulation of the hypothalamic-pituitary-adrenal axis.
These bidirectional effects highlight a tightly controlled balance between
neuroendocrine stimuli and macrophage function in the development of innate and
adaptive immune responses. Herein, we discuss how components of neuroendocrine
axes impact on macrophage development and function and may ultimately influence
inflammation, tissue repair, infection, or cancer progression. The knowledge of
the crosstalk between macrophages and endocrine or brain-derived components may
contribute to improve and create new approaches with clinical relevance in
homeostatic or pathological conditions.