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2013 ; 13
(6
): 397-411
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Neuroblastoma: developmental biology, cancer genomics and immunotherapy
#MMPMID23702928
Cheung NK
; Dyer MA
Nat Rev Cancer
2013[Jun]; 13
(6
): 397-411
PMID23702928
show ga
Neuroblastoma is a solid tumour that arises from the developing sympathetic
nervous system. Over the past decade, our understanding of this disease has
advanced tremendously. The future challenge is to apply the knowledge gained to
developing risk-based therapies and, ultimately, improving outcome. In this
Review we discuss the key discoveries in the developmental biology, molecular
genetics and immunology of neuroblastoma, as well as new translational tools for
bringing these promising scientific advances into the clinic.