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2017 ; 33
(17
): 2723-2730
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Neuro-symbolic representation learning on biological knowledge graphs
#MMPMID28449114
Alshahrani M
; Khan MA
; Maddouri O
; Kinjo AR
; Queralt-Rosinach N
; Hoehndorf R
Bioinformatics
2017[Sep]; 33
(17
): 2723-2730
PMID28449114
show ga
MOTIVATION: Biological data and knowledge bases increasingly rely on Semantic Web
technologies and the use of knowledge graphs for data integration, retrieval and
federated queries. In the past years, feature learning methods that are
applicable to graph-structured data are becoming available, but have not yet
widely been applied and evaluated on structured biological knowledge. Results: We
develop a novel method for feature learning on biological knowledge graphs. Our
method combines symbolic methods, in particular knowledge representation using
symbolic logic and automated reasoning, with neural networks to generate
embeddings of nodes that encode for related information within knowledge graphs.
Through the use of symbolic logic, these embeddings contain both explicit and
implicit information. We apply these embeddings to the prediction of edges in the
knowledge graph representing problems of function prediction, finding candidate
genes of diseases, protein-protein interactions, or drug target relations, and
demonstrate performance that matches and sometimes outperforms traditional
approaches based on manually crafted features. Our method can be applied to any
biological knowledge graph, and will thereby open up the increasing amount of
Semantic Web based knowledge bases in biology to use in machine learning and data
analytics. AVAILABILITY AND IMPLEMENTATION:
https://github.com/bio-ontology-research-group/walking-rdf-and-owl. CONTACT:
robert.hoehndorf@kaust.edu.sa. SUPPLEMENTARY INFORMATION: Supplementary data are
available at Bioinformatics online.