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2012 ; 4
(ä): 13-25
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Neuro-ophthalmic sarcoidosis
#MMPMID28539778
Baughman RP
; Weiss KL
; Golnik KC
Eye Brain
2012[]; 4
(ä): 13-25
PMID28539778
show ga
Neuro-ophthalmic disease occurs in about a third of patients with
neurosarcoidosis. Optic nerve involvement is the most common manifestation, but
other cranial nerves and the optic chiasm can be involved. However, there are
several other common diseases that cause optic neuropathy, including multiple
sclerosis. The diagnosis of sarcoidosis can often be made based on the
multi-organ nature of the disease and ancillary testing. Most patients with
neuro-ophthalmic sarcoidosis require systemic therapy. While corticosteroids are
usually the first step in therapy, cytotoxic agents such as methotrexate and
azathioprine have been useful as steroid-sparing agents for chronic disease. The
monoclonal antibodies directed against tumor necrosis factor have been reported
as effective in refractory cases of neuro-ophthalmic disease.