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2014 ; 29
(6
): 956-60
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Neuro-Behçet s disease: an unusual cause of headache
#MMPMID24549519
Fountain EM
; Dhurandhar A
J Gen Intern Med
2014[Jun]; 29
(6
): 956-60
PMID24549519
show ga
Neuro-Behçet's disease (NBD) is a potentially fatal complication of Behçet's
disease (BD) that can sometimes masquerade as a primary neoplasm, aseptic
meningitis or multiple sclerosis. Headache in patients with BD may portend onset
of NBD, but the majority of headache in BD is benign. Clinicians who are unaware
of the specific neurological manifestations of systemic inflammatory disorders
like BD may fail to consider the possibility of serious intracranial pathology.
We illustrate these challenges with the case of a 50-year-old woman with a
history of BD who presented with headache in the absence of initial focal
neurological deficits. The diagnosis of NBD was missed on multiple occasions
before the correct diagnosis was made. We describe the etiology of headache in
BD, the specific neurological manifestations of BD that suggest NBD, and the
utility of routine neurological exams for BD patients with chronic headache. We
further discuss the appropriate use of neuroimaging for headache in BD, and we
recommend consideration of NBD as a diagnosis for headache in patients suspected
of having an underlying systemic disease.