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10.1016/j.neuron.2015.08.001 http://scihub22266oqcxt.onion/10.1016/j.neuron.2015.08.001 C4559867!4559867 !26335642     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26335642 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Neuron 2015 ; 87 (5 ): 946-61 Nephropedia Template TP {{tp|p=26335642 |t=2015. Neural Control of Breathing and CO2 Homeostasis |pdf=|usr=}}{{26335642 }} gab.com Text Neural Control of Breathing and CO2 Homeostasis JO: Neuron http://www.kidney.de/pget.php?&tw=1&pmid=26335642 #FOAvip Recent advances have clarified how the brain detects CO2 to regulate breathing (central respiratory chemoreception). These mechanisms are reviewed and their significance is presented in the general context of CO2/pH homeostasis through breathing. At rest, respiratory chemoreflexes initiated at peripheral and central sites mediate rapid stabilization of arterial PCO2 and pH. Specific brainstem neurons (e.g., retrotrapezoid nucleus, RTN; serotonergic) are activated by PCO2 and stimulate breathing. RTN neurons detect CO2 via intrinsic proton receptors (TASK-2, GPR4), synaptic input from peripheral chemoreceptors and signals from astrocytes. Respiratory chemoreflexes are arousal state dependent whereas chemoreceptor stimulation produces arousal. When abnormal, these interactions lead to sleep-disordered breathing. During exercise, central command and reflexes from exercising muscles produce the breathing stimulation required to maintain arterial PCO2 and pH despite elevated metabolic activity. The neural circuits underlying central command and muscle afferent control of breathing remain elusive and represent a fertile area for future investigation. Twit Text FOAVip Neural Control of Breathing and CO2 Homeostasis ????Neuron http://www.kidney.de/pget.php?&tw=1&pmid=26335642 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26335642 #FOAvip English Wikipedia <ref>{{Cite pmid|26335642 }}</ref> Neural Control of Breathing and CO2 Homeostasis #MMPMID26335642 Guyenet PG ; Bayliss DA Neuron 2015[Sep]; 87 (5 ): 946-61 PMID26335642 show ga Recent advances have clarified how the brain detects CO2 to regulate breathing (central respiratory chemoreception). These mechanisms are reviewed and their significance is presented in the general context of CO2/pH homeostasis through breathing. At rest, respiratory chemoreflexes initiated at peripheral and central sites mediate rapid stabilization of arterial PCO2 and pH. Specific brainstem neurons (e.g., retrotrapezoid nucleus, RTN; serotonergic) are activated by PCO2 and stimulate breathing. RTN neurons detect CO2 via intrinsic proton receptors (TASK-2, GPR4), synaptic input from peripheral chemoreceptors and signals from astrocytes. Respiratory chemoreflexes are arousal state dependent whereas chemoreceptor stimulation produces arousal. When abnormal, these interactions lead to sleep-disordered breathing. During exercise, central command and reflexes from exercising muscles produce the breathing stimulation required to maintain arterial PCO2 and pH despite elevated metabolic activity. The neural circuits underlying central command and muscle afferent control of breathing remain elusive and represent a fertile area for future investigation. |*Respiration/drug effects [MESH] |Animals [MESH] |Carbon Dioxide/*metabolism [MESH] |Chemoreceptor Cells/drug effects/*physiology [MESH] |Homeostasis/*physiology [MESH] |Humans [MESH]Neural Control of Breathing and CO2 Homeostasis (epmc).pdf DeepDyve Pubget Overpricing