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2016 ; 127
(ä): 123-134
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Network mechanisms of intentional learning
#MMPMID26658925
Hampshire A
; Hellyer PJ
; Parkin B
; Hiebert N
; MacDonald P
; Owen AM
; Leech R
; Rowe J
Neuroimage
2016[Feb]; 127
(ä): 123-134
PMID26658925
show ga
The ability to learn new tasks rapidly is a prominent characteristic of human
behaviour. This ability relies on flexible cognitive systems that adapt in order
to encode temporary programs for processing non-automated tasks. Previous
functional imaging studies have revealed distinct roles for the lateral frontal
cortices (LFCs) and the ventral striatum in intentional learning processes.
However, the human LFCs are complex; they house multiple distinct sub-regions,
each of which co-activates with a different functional network. It remains
unclear how these LFC networks differ in their functions and how they coordinate
with each other, and the ventral striatum, to support intentional learning. Here,
we apply a suite of fMRI connectivity methods to determine how LFC networks
activate and interact at different stages of two novel tasks, in which arbitrary
stimulus-response rules are learnt either from explicit instruction or by
trial-and-error. We report that the networks activate en masse and in synchrony
when novel rules are being learnt from instruction. However, these networks are
not homogeneous in their functions; instead, the directed connectivities between
them vary asymmetrically across the learning timecourse and they disengage from
the task sequentially along a rostro-caudal axis. Furthermore, when negative
feedback indicates the need to switch to alternative stimulus-response rules,
there is additional input to the LFC networks from the ventral striatum. These
results support the hypotheses that LFC networks interact as a hierarchical
system during intentional learning and that signals from the ventral striatum
have a driving influence on this system when the internal program for processing
the task is updated.