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2009 ; 2
(2
): 176-84
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Network based models for biological applications
#MMPMID20108537
Dobrescu R
; Purc?rea V
J Med Life
2009[Apr]; 2
(2
): 176-84
PMID20108537
show ga
This paper analyses the adequacy of different types of networks in biological
process modeling. The assumptions are sustained by two case studies. The first
one is a lattice-based computer model to simulate the growth of nonvascular
tumors with nutrient consumption constraints. The modeling solution is able to
reproduce the classic three-layer structure familiar from multicellular
spheroids: cell proliferation, quiescent and necrosis. The accuracy of this model
is tested by comparing it to a fractal morphometric technique of two patterns,
one of them obtained by simulation, the other developed in vitro. The second
application is the growth of a directed network, in which the growth is
constrained by the cost of adding links to the existing nodes. This is a new
preferential attachment scheme, different from those specific for the
construction of scale-free graphs, because its new nodes prefer to attach to
existing nodes with lower degree. We relate this mechanism to a simple food-web
model studied by simulations.
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