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10.1038/ncomms12706 http://scihub22266oqcxt.onion/10.1038/ncomms12706 C5025806!5025806 !27586429     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27586429 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27586429 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): 12706 Nephropedia Template TP {{tp|p=27586429 |t=2016. Nestin(+) cells direct inflammatory cell migration in atherosclerosis |pdf=|usr=}}{{27586429 }} gab.com Text Nestin(+) cells direct inflammatory cell migration in atherosclerosis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27586429 #FOAvip Atherosclerosis is a leading death cause. Endothelial and smooth muscle cells participate in atherogenesis, but it is unclear whether other mesenchymal cells contribute to this process. Bone marrow (BM) nestin(+) cells cooperate with endothelial cells in directing monocyte egress to bloodstream in response to infections. However, it remains unknown whether nestin(+) cells regulate inflammatory cells in chronic inflammatory diseases, such as atherosclerosis. Here, we show that nestin(+) cells direct inflammatory cell migration during chronic inflammation. In Apolipoprotein E (ApoE) knockout mice fed with high-fat diet, BM nestin(+) cells regulate the egress of inflammatory monocytes and neutrophils. In the aorta, nestin(+) stromal cells increase ?30 times and contribute to the atheroma plaque. Mcp1 deletion in nestin(+) cells-but not in endothelial cells only- increases circulating inflammatory cells, but decreases their aortic infiltration, delaying atheroma plaque formation and aortic valve calcification. Therefore, nestin expression marks cells that regulate inflammatory cell migration during atherosclerosis. Twit Text FOAVip Nestin(+) cells direct inflammatory cell migration in atherosclerosis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27586429 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27586429 #FOAvip English Wikipedia <ref>{{Cite pmid|27586429 }}</ref> Nestin(+) cells direct inflammatory cell migration in atherosclerosis #MMPMID27586429 Del Toro R ; Chčvre R ; Rodríguez C ; Ordóńez A ; Martínez-González J ; Andrés V ; Méndez-Ferrer S Nat Commun 2016[Sep]; 7 (ä): 12706 PMID27586429 show ga Atherosclerosis is a leading death cause. Endothelial and smooth muscle cells participate in atherogenesis, but it is unclear whether other mesenchymal cells contribute to this process. Bone marrow (BM) nestin(+) cells cooperate with endothelial cells in directing monocyte egress to bloodstream in response to infections. However, it remains unknown whether nestin(+) cells regulate inflammatory cells in chronic inflammatory diseases, such as atherosclerosis. Here, we show that nestin(+) cells direct inflammatory cell migration during chronic inflammation. In Apolipoprotein E (ApoE) knockout mice fed with high-fat diet, BM nestin(+) cells regulate the egress of inflammatory monocytes and neutrophils. In the aorta, nestin(+) stromal cells increase ?30 times and contribute to the atheroma plaque. Mcp1 deletion in nestin(+) cells-but not in endothelial cells only- increases circulating inflammatory cells, but decreases their aortic infiltration, delaying atheroma plaque formation and aortic valve calcification. Therefore, nestin expression marks cells that regulate inflammatory cell migration during atherosclerosis. |Animals [MESH] |Aorta/cytology/pathology [MESH] |Apolipoproteins E/genetics [MESH] |Atherosclerosis/*pathology [MESH] |Cell Movement/*physiology [MESH] |Chemokine CCL2/*genetics [MESH] |Diet, High-Fat [MESH] |Endothelial Cells/*pathology [MESH] |Inflammation/pathology [MESH] |Mesoderm/*cytology/pathology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Monocytes/immunology [MESH] |Nestin/*metabolism [MESH] |Neutrophils/immunology [MESH]Nestin(+) cells direct inflammatory cell migration in atherosclerosis (epmc).pdf DeepDyve Pubget Overpricing