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2016 ; 6
(2
): 85-8
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Nephrotic syndrome-induced thromboembolism in adults
#MMPMID27308257
Al-Azzawi HF
; Obi OC
; Safi J
; Song M
Int J Crit Illn Inj Sci
2016[Apr]; 6
(2
): 85-8
PMID27308257
show ga
Nephrotic syndrome (NS) is a well-defined syndrome characterized by the presence
of nephrotic range of proteinuria, hypoalbuminemia, and hyperlipidemia. Although
venous thromboembolism (VTE) is a well-reported complication associated with NS,
the incidence, prevalence, risk factors, treatment options, and preventative
strategies are not well-established. Thromboembolic phenomena in nephrotic
patients are postulated to be a result of the urinary loss of antithrombotic
factors by affected kidneys and increased production of prothrombotic factors by
the liver. Most cases of VTE associated with NS reported in the literature have a
known diagnosis of NS. We report a case of a young female presenting with dyspnea
and a pulmonary embolism. She was found to have NS and right renal vein
thrombosis. We review the available literature to highlight the best approach for
clinicians treating VTE in patients with NS.