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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Dev+Ophthalmol
2016 ; 55
(ä): 196-204
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English Wikipedia
Neovascular Glaucoma
#MMPMID26501989
Havens SJ
; Gulati V
Dev Ophthalmol
2016[]; 55
(ä): 196-204
PMID26501989
show ga
Neovascular glaucoma (NVG) is a secondary ocular pathological condition resulting
from a myriad of ocular and systemic conditions with retinal ischemia as a
mediator in over 95% of cases. NVG is caused by the growth of a fibrovascular
membrane secondary to a local angiogenic stimulus over the trabecular meshwork
obstructing aqueous outflow. This results in an initial secondary open-angle
glaucoma stage that may be amenable to intraocular pressure (IOP)-lowering
medications and modulation of the underlying ischemic process, often in
combination with panretinal photocoagulation and adjunctive use of vascular
endothelial growth factor inhibitors. In the more advanced stages of
neovascularization, connective tissue myofibroblasts associated with new vessel
growth contract causing progressive synechial closure of the anterior-chamber
angle. Elevation of IOP, once significant secondary angle closure is established,
tends to be refractory to topical and oral IOP-lowering medications and often
requires glaucoma surgical interventions.
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