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2015 ; 19
(9
): 523-7
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Neonatal mechanical ventilation: Indications and outcome
#MMPMID26430338
Iqbal Q
; Younus MM
; Ahmed A
; Ahmad I
; Iqbal J
; Charoo BA
; Ali SW
Indian J Crit Care Med
2015[Sep]; 19
(9
): 523-7
PMID26430338
show ga
BACKGROUND AND AIMS: Decreasing mortality in sick and ventilated neonates is an
endeavor of all neonatologists. To reduce the high mortality in this group of
neonates, identification of risk factors is important. This study was undertaken
to find out the indications of ventilation and complications in ventilated
neonates and also study possible predictors of outcome. SUBJECTS: Age <1-month;
mechanically ventilated; not having suspected metabolic disorders or congenital
anomalies; excluding postoperative patients. METHODS: Neonates consecutively put
on mechanical ventilation during the study period (October 2011 to November 2013)
enrolled. Primary disease of the neonates along with complications present
listed. Clinical and laboratory parameters analyzed to find the predictors of
mortality. RESULTS: Total 300 neonates were ventilated. 52% were male. Mean age,
weight, and gestational age were 21 ± 62 h, 2320 ± 846.2 g, and 35.2 ± 4.9 weeks,
respectively. 130 (43%) neonates died. Respiratory distress syndrome (RDS)
(31.1%), sepsis (22.7%), and birth asphyxia (18%) were the most common
indications for ventilation. Mortality in ventilated patients with sepsis,
pneumonia, RDS or birth asphyxia was 64.7%, 60%, 44.6%, and 33.3%, respectively.
Weight <2500 g, gestation <34 weeks, initial pH <7.1, presence of sepsis, apnea,
shock, pulmonary hemorrhage, hypoglycemia, neutropenia, and thrombocytopenia were
significantly associated with mortality (P < 0.05). Resuscitation at birth,
seizures, intra ventricular hemorrhage, pneumothorax, ventilator-associated
pneumonia, PO2, or PCO2 did not have a significant association with mortality. On
logistic regression, gestation <34 weeks, initial pH <7.1, pulmonary hemorrhage,
or shock were independently significant predictors of mortality. CONCLUSIONS:
Weight <2500 g, gestation <34 weeks, initial arterial pH <7.1, shock, pulmonary
hemorrhage, apnea, hypoglycemia, neutropenia, and thrombocytopenia were
significant predictors of mortality in ventilated neonates.