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2016 ; 6
(1
): e42-7
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Neonatal Thrombocytopenia as a Consequence of Maternal Preeclampsia
#MMPMID26929869
Kalagiri RR
; Choudhury S
; Carder T
; Govande V
; Beeram MR
; Uddin MN
AJP Rep
2016[Mar]; 6
(1
): e42-7
PMID26929869
show ga
Introduction?Preeclampsia (preE) is pregnancy-induced hypertension affecting a
significant proportion of pregnant women worldwide and can cause detrimental
effects in the mother and newborn. Some of the effects in the newborn include
neonatal thrombocytopenia. Pertaining specifically to neonatal thrombocytopenia,
several questions remain unanswered. Discussion?According to the current
literature, neonatal thrombocytopenia due to maternal preE is highly prevalent in
the general population and the incidence is reported to be around 30% worldwide.
This review gives an insight into the syndrome and summarizes the possible
pathological mechanisms, the diagnostic approach, complications, and therapeutic
interventions of neonatal thrombocytopenia. It also identifies the involvement of
other cell lines, apart from platelets in the newborns. Furthermore, we suggest a
future prospective study to investigate the pathogenesis of preE and plan a study
involving animal models to come up with a possible therapeutic intervention to
prevent preE and its various consequences in neonates.