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Negative occasion setting in juvenile rats
#MMPMID27215319
Meyer HC
; Bucci DJ
Behav Processes
2017[Apr]; 137
(?): 33-39
PMID27215319
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Prior findings indicate that adolescent rats exhibit difficulty using negative
occasion setters to guide behavior compared to adult rats (Meyer and Bucci,
2014). Here, additional groups of juvenile rats were trained in the same negative
occasion setting procedure to further define the development of negative occasion
setting. Beginning on either postnatal day (PND) 30, 40, or 50, rats received
daily training sessions in which a tone was paired with food reinforcement on
some trials, while on other trials a light preceded the tone and no reinforcement
was delivered. We found that rats that began training on PND 50 required 10
training sessions to discriminate between the two types of trials, consistent
with prior findings with young adult rats. Interestingly, rats in the PND 30
group (pre-adolescents) also required just 10 training sessions, in stark
contrast to adolescent rats that began training on PND 35 (adolescents) and
required 18 sessions (Meyer and Bucci, 2014). Rats that began training on PND 40
(adolescents) also required more sessions than the PND 30 group. These data
indicate that the development of negative occasion setting is non-linear and have
direct bearing on understanding the behavioral and neural substrates that
underlie suboptimal behavioral control in adolescents.
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