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2015 ; 5
(4
): 192-9
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English Wikipedia
Needle free injection technology: A complete insight
#MMPMID26682189
Ravi AD
; Sadhna D
; Nagpaal D
; Chawla L
Int J Pharm Investig
2015[Oct]; 5
(4
): 192-9
PMID26682189
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Needle free injection technology (NFIT)is an extremely broad concept which
include a wide range of drug delivery systems that drive drugs through the skin
using any of the forces as Lorentz, Shock waves, pressure by gas or
electrophoresis which propels the drug through the skin, virtually nullifying the
use of hypodermic needle. This technology is not only touted to be beneficial for
the pharma industry but developing world too find it highly useful in mass
immunization programmes, bypassing the chances of needle stick injuries and
avoiding other complications including those arising due to multiple use of
single needle. The NFIT devices can be classified based on their working, type of
load, mechanism of drug delivery and site of delivery. To administer a stable,
safe and an effective dose through NFIT, the sterility, shelf life and viscosity
of drug are the main components which should be taken care of. Technically
superior needle-free injection systems are able to administer highly viscous drug
products which cannot be administered by traditional needle and syringe systems,
further adding to the usefulness of the technology. NFIT devices can be
manufactured in a variety of ways; however the widely employed procedure to
manufacture it is by injection molding technique. There are many variants of this
technology which are being marketed, such as Bioject(®) ZetaJetTM, Vitajet 3,
Tev-Tropin(®) and so on. Larger investment has been made in developing this
technology with several devices already being available in the market post FDA
clearance and a great market worldwide.
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