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10.1038/nrgastro.2016.119 http://scihub22266oqcxt.onion/10.1038/nrgastro.2016.119 C5124124!5124124 !27534694     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27534694 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Rev+Gastroenterol+Hepatol 2016 ; 13 (10 ): 590-600 Nephropedia Template TP {{tp|p=27534694 |t=2016. Necrotizing enterocolitis: new insights into pathogenesis and mechanisms |pdf=|usr=}}{{27534694 }} gab.com Text Necrotizing enterocolitis: new insights into pathogenesis and mechanisms JO: Nat Rev Gastroenterol Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=27534694 #FOAvip Necrotizing enterocolitis (NEC) is the most frequent and lethal disease of the gastrointestinal tract of preterm infants. At present, NEC is thought to develop in the premature host in the setting of bacterial colonization, often after administration of non-breast milk feeds, and disease onset is thought to be due in part to a baseline increased reactivity of the premature intestinal mucosa to microbial ligands as compared with the full-term intestinal mucosa. The increased reactivity leads to mucosal destruction and impaired mesenteric perfusion and partly reflects an increased expression of the bacterial receptor Toll-like receptor 4 (TLR4) in the premature gut, as well as other factors that predispose the intestine to a hyper-reactive state in response to colonizing microorganisms. The increased expression of TLR4 in the premature gut reflects a surprising role for this molecule in the regulation of normal intestinal development through its effects on the Notch signalling pathway. This Review will examine the current approach to the diagnosis and treatment of NEC, provide an overview of our current knowledge regarding its molecular underpinnings and highlight advances made within the past decade towards the development of specific preventive and treatment strategies for this devastating disease. Twit Text FOAVip Necrotizing enterocolitis: new insights into pathogenesis and mechanisms ????Nat Rev Gastroenterol Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=27534694 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27534694 #FOAvip English Wikipedia <ref>{{Cite pmid|27534694 }}</ref> Necrotizing enterocolitis: new insights into pathogenesis and mechanisms #MMPMID27534694 Niņo DF ; Sodhi CP ; Hackam DJ Nat Rev Gastroenterol Hepatol 2016[Oct]; 13 (10 ): 590-600 PMID27534694 show ga Necrotizing enterocolitis (NEC) is the most frequent and lethal disease of the gastrointestinal tract of preterm infants. At present, NEC is thought to develop in the premature host in the setting of bacterial colonization, often after administration of non-breast milk feeds, and disease onset is thought to be due in part to a baseline increased reactivity of the premature intestinal mucosa to microbial ligands as compared with the full-term intestinal mucosa. The increased reactivity leads to mucosal destruction and impaired mesenteric perfusion and partly reflects an increased expression of the bacterial receptor Toll-like receptor 4 (TLR4) in the premature gut, as well as other factors that predispose the intestine to a hyper-reactive state in response to colonizing microorganisms. The increased expression of TLR4 in the premature gut reflects a surprising role for this molecule in the regulation of normal intestinal development through its effects on the Notch signalling pathway. This Review will examine the current approach to the diagnosis and treatment of NEC, provide an overview of our current knowledge regarding its molecular underpinnings and highlight advances made within the past decade towards the development of specific preventive and treatment strategies for this devastating disease. |Animals [MESH] |Biological Factors/therapeutic use [MESH] |Biomarkers/metabolism [MESH] |Breast Feeding [MESH] |Disease Models, Animal [MESH] |Disease Susceptibility [MESH] |Enterocolitis, Necrotizing/diagnosis/etiology/*prevention & control [MESH] |Gastrointestinal Microbiome/physiology [MESH] |Humans [MESH] |Infant, Newborn [MESH] |Infant, Premature [MESH] |Infant, Premature, Diseases/diagnosis/etiology/*therapy [MESH] |Probiotics/therapeutic use [MESH]Necrotizing enterocolitis: new insights into pathogenesis and mechanis(epmc).pdf DeepDyve Pubget Overpricing