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10.1016/j.semcdb.2014.07.003 http://scihub22266oqcxt.onion/10.1016/j.semcdb.2014.07.003 C4197103!4197103!25042848     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25042848.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Semin+Cell+Dev+Biol 2014 ; ä (ä): 33-9 Nephropedia Template TP {{tp|p=25042848|t=2014. Necroptotic signaling in adaptive and innate immunity |pdf=|usr=}}{{25042848}} gab.com Text Necroptotic signaling in adaptive and innate immunity JO: Semin Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=25042848 #FOAvip The vertebrate immune system is highly dependent on cell death for efficient responsiveness to microbial pathogens and oncogenically transformed cells. Cell death pathways are vital to the function of many immune cell types during innate, humoral and cellular immune responses. In addition, cell death regulation is imperative for proper adaptive immune self-tolerance and homeostasis. While apoptosis has been found to be involved in several of these roles in immunity, recent data demonstrate that alternative cell death pathways are required. Here, we describe the involvement of a programmed form of cellular necrosis called ?necroptosis? in immunity. We consider the signaling pathways that promote necroptosis downstream of death receptors, type I transmembrane proteins of the tumor necrosis factor (TNF) receptor family. The involvement of necroptotic signaling through a ?RIPoptosome? assembled in response to innate immune stimuli or genotoxic stress is described. We also characterize the induction of necroptosis following antigenic stimulation in T cells lacking caspase-8 or FADD function. While necroptotic signaling remains poorly understood, it is clear that this pathway is an essential component to effective vertebrate immunity. Twit Text FOAVip Necroptotic signaling in adaptive and innate immunity ????Semin Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=25042848 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25042848 #FOAvip English Wikipedia <ref>{{Cite pmid|25042848}}</ref> Necroptotic signaling in adaptive and innate immunity #MMPMID25042848 Lu JV; Chen HC; Walsh CM Semin Cell Dev Biol 2014[Nov]; ä (ä): 33-9 PMID25042848show ga The vertebrate immune system is highly dependent on cell death for efficient responsiveness to microbial pathogens and oncogenically transformed cells. Cell death pathways are vital to the function of many immune cell types during innate, humoral and cellular immune responses. In addition, cell death regulation is imperative for proper adaptive immune self-tolerance and homeostasis. While apoptosis has been found to be involved in several of these roles in immunity, recent data demonstrate that alternative cell death pathways are required. Here, we describe the involvement of a programmed form of cellular necrosis called ?necroptosis? in immunity. We consider the signaling pathways that promote necroptosis downstream of death receptors, type I transmembrane proteins of the tumor necrosis factor (TNF) receptor family. The involvement of necroptotic signaling through a ?RIPoptosome? assembled in response to innate immune stimuli or genotoxic stress is described. We also characterize the induction of necroptosis following antigenic stimulation in T cells lacking caspase-8 or FADD function. While necroptotic signaling remains poorly understood, it is clear that this pathway is an essential component to effective vertebrate immunity. äNecroptotic signaling in adaptive and innate immunity (epmc).pdf DeepDyve Pubget Overpricing