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2017 ; 3
(4
): 294-301
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Necroptosis and Cancer
#MMPMID28451648
Najafov A
; Chen H
; Yuan J
Trends Cancer
2017[Apr]; 3
(4
): 294-301
PMID28451648
show ga
Necroptosis is a programmed lytic cell death pathway, deregulation of which is
linked to various inflammatory disorders. Escape from programmed cell death and
inflammation play a significant role in cancer, and therefore, investigating the
role of necroptosis in cancer has been of high interest. Necroptosis has been
shown to promote cancer metastasis and T cells death. Escape from necroptosis via
loss of RIPK3 expression is a feature of some cancers. While necroptosis is a
promising novel target for cancer therapies, further investigation into its
biological role in carcinogenesis is warranted. In this article, we review the
recently-identified interplay points between necroptosis and cancer, and outline
major biological questions that require further inquiry on the road to targeting
this pathway in cancer.