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Nanowire arrays restore vision in blind mice
#MMPMID29511183
Tang J
; Qin N
; Chong Y
; Diao Y
; Yiliguma
; Wang Z
; Xue T
; Jiang M
; Zhang J
; Zheng G
Nat Commun
2018[Mar]; 9
(1
): 786
PMID29511183
show ga
The restoration of light response with complex spatiotemporal features in retinal
degenerative diseases towards retinal prosthesis has proven to be a considerable
challenge over the past decades. Herein, inspired by the structure and function
of photoreceptors in retinas, we develop artificial photoreceptors based on gold
nanoparticle-decorated titania nanowire arrays, for restoration of visual
responses in the blind mice with degenerated photoreceptors. Green, blue and near
UV light responses in the retinal ganglion cells (RGCs) are restored with a
spatial resolution better than 100?µm. ON responses in RGCs are blocked by
glutamatergic antagonists, suggesting functional preservation of the remaining
retinal circuits. Moreover, neurons in the primary visual cortex respond to light
after subretinal implant of nanowire arrays. Improvement in pupillary light
reflex suggests the behavioral recovery of light sensitivity. Our study will shed
light on the development of a new generation of optoelectronic toolkits for
subretinal prosthetic devices.
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