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2016 ; 99
(Pt A
): 52-69
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gab.com Text
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Nanotechnology inspired tools for mitochondrial dysfunction related diseases
#MMPMID26776231
Wen R
; Banik B
; Pathak RK
; Kumar A
; Kolishetti N
; Dhar S
Adv Drug Deliv Rev
2016[Apr]; 99
(Pt A
): 52-69
PMID26776231
show ga
Mitochondrial dysfunctions are recognized as major factors for various diseases
including cancer, cardiovascular diseases, diabetes, neurological disorders, and
a group of diseases so called "mitochondrial dysfunction related diseases". One
of the major hurdles to gain therapeutic efficiency in diseases where the targets
are located in the mitochondria is the accessibility of the targets in this
compartmentalized organelle that imposes barriers toward internalization of ions
and molecules. Over the time, different tools and techniques were developed to
improve therapeutic index for mitochondria acting drugs. Nanotechnology has
unfolded as one of the logical and encouraging tools for delivery of therapeutics
in controlled and targeted manner simultaneously reducing side effects from drug
overdose. Tailor-made nanomedicine based therapeutics can be an excellent tool in
the toolbox for diseases associated with mitochondrial dysfunctions. In this
review, we present an extensive coverage of possible therapeutic targets in
different compartments of mitochondria for cancer, cardiovascular, and
mitochondrial dysfunction related diseases.