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2014 ; 5
(ä): 25-35
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Nanotechnology in the Regeneration of Complex Tissues
#MMPMID26097381
Cassidy JW
Bone Tissue Regen Insights
2014[Nov]; 5
(ä): 25-35
PMID26097381
show ga
Modern medicine faces a growing crisis as demand for organ transplantations
continues to far outstrip supply. By stimulating the body's own repair
mechanisms, regenerative medicine aims to reduce demand for organs, while the
closely related field of tissue engineering promises to deliver "off-the-self"
organs grown from patients' own stem cells to improve supply. To deliver on these
promises, we must have reliable means of generating complex tissues. Thus far,
the majority of successful tissue engineering approaches have relied on
macroporous scaffolds to provide cells with both mechanical support and
differentiative cues. In order to engineer complex tissues, greater attention
must be paid to nanoscale cues present in a cell's microenvironment. As the
extracellular matrix is capable of driving complexity during development, it must
be understood and reproduced in order to recapitulate complexity in engineered
tissues. This review will summarize current progress in engineering complex
tissue through the integration of nanocomposites and biomimetic scaffolds.