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10.1039/c6ib00113k http://scihub22266oqcxt.onion/10.1039/c6ib00113k C5021613!5021613!27477049     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27477049.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Integr+Biol+(Camb) 2016 ; 8 (9): 929-35 Nephropedia Template TP {{tp|p=27477049|t=2016. Nanoscale Mechanics Guides Cellular Decision Making |pdf=|usr=}}{{27477049}} gab.com Text Nanoscale Mechanics Guides Cellular Decision Making JO: Integr Biol (Camb) http://www.kidney.de/pget.php?&tw=1&pmid=27477049 #FOAvip This study used novel, force-limited nanoscale tension gauges to investigate how force and substrate stiffness guide cellular decision-making during initial cell attachment and spreading on deformable substrates. The well-established dependence of cell traction and spreading on substrate stiffness has been attributed to levels of force exerted on molecular components in focal contacts. The molecular tension gauges used in this study enabled direct estimates of threshold, pico Newton forces that instructed decision-making at different stages of cell attachment, spreading, and adhesion maturation. Results show that the force thresholds controlling cellular adhesion and spreading transitions depend on substrate stiffness. Reported findings agree qualitatively with a proposed model that attributes rigidity-dependent differences in cell spreading to stiffness-dependent rates of competing biochemical processes. Moreover, estimated magnitudes of force thresholds governing transitions in cell attachment and spreading, based on these in situ measurements, were in remarkable agreement with prior less direct measurements. Twit Text FOAVip Nanoscale Mechanics Guides Cellular Decision Making ????Integr Biol (Camb) http://www.kidney.de/pget.php?&tw=1&pmid=27477049 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27477049 #FOAvip English Wikipedia <ref>{{Cite pmid|27477049}}</ref> Nanoscale Mechanics Guides Cellular Decision Making #MMPMID27477049 Rahil Z; Pedron S; Wang X; Ha T; Harley B; Leckband L Integr Biol (Camb) 2016[Sep]; 8 (9): 929-35 PMID27477049show ga This study used novel, force-limited nanoscale tension gauges to investigate how force and substrate stiffness guide cellular decision-making during initial cell attachment and spreading on deformable substrates. The well-established dependence of cell traction and spreading on substrate stiffness has been attributed to levels of force exerted on molecular components in focal contacts. The molecular tension gauges used in this study enabled direct estimates of threshold, pico Newton forces that instructed decision-making at different stages of cell attachment, spreading, and adhesion maturation. Results show that the force thresholds controlling cellular adhesion and spreading transitions depend on substrate stiffness. Reported findings agree qualitatively with a proposed model that attributes rigidity-dependent differences in cell spreading to stiffness-dependent rates of competing biochemical processes. Moreover, estimated magnitudes of force thresholds governing transitions in cell attachment and spreading, based on these in situ measurements, were in remarkable agreement with prior less direct measurements. äNanoscale Mechanics Guides Cellular Decision Making (epmc).pdf DeepDyve Pubget Overpricing