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2015 ; 5
(9
): 1030-44
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Nanoparticles for Radiation Therapy Enhancement: the Key Parameters
#MMPMID26155318
Retif P
; Pinel S
; Toussaint M
; Frochot C
; Chouikrat R
; Bastogne T
; Barberi-Heyob M
Theranostics
2015[]; 5
(9
): 1030-44
PMID26155318
show ga
This review focuses on the radiosensitization strategies that use high-Z
nanoparticles. It does not establish an exhaustive list of the works in this
field but rather propose constructive criticisms pointing out critical factors
that could improve the nano-radiation therapy. Whereas most reviews show the
chemists and/or biologists points of view, the present analysis is also seen
through the prism of the medical physicist. In particular, we described and
evaluated the influence of X-rays energy spectra using a numerical analysis. We
observed a lack of standardization in preclinical studies that could partially
explain the low number of translation to clinical applications for this
innovative therapeutic strategy. Pointing out the critical parameters of high-Z
nanoparticles radiosensitization, this review is expected to contribute to a
larger preclinical and clinical development.