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2017 ; 4
(3
): 1600279
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Nanoparticle Functionalization and Its Potentials for Molecular Imaging
#MMPMID28331783
Thiruppathi R
; Mishra S
; Ganapathy M
; Padmanabhan P
; Gulyás B
Adv Sci (Weinh)
2017[Mar]; 4
(3
): 1600279
PMID28331783
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Functionalization enhances the properties and characteristics of nanoparticles
through surface modification, and enables them to play a major role in the field
of medicine. In molecular imaging, quality functional images are required with
proper differentiation which can be seen with high contrast to obtain viable
information. This review article discusses how functionalization enhances
molecular imaging and enables multimodal imaging by which images with combination
of functions particular to each modality can be obtained. This also explains how
nanoparticles interacting at molecular level, when functionalized with molecules
can target the cells of interest or substances with high specificity, reducing
background signal and allowing simultaneous therapies to be carried out while
imaging. Functionalization allows imaging for a prolonged period and enables to
track the cells over a period of time. Recent researches and progress in
functionalizing the nanoparticles to specifically enhance bioimaging with
different modalities and their applications are reviewed in this article.
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