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2015 ; 7
(3
): 355-70
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Nanomaterials, inflammation, and tissue engineering
#MMPMID25421333
Padmanabhan J
; Kyriakides TR
Wiley Interdiscip Rev Nanomed Nanobiotechnol
2015[May]; 7
(3
): 355-70
PMID25421333
show ga
Nanomaterials exhibit unique properties that are absent in the bulk material
because decreasing material size leads to an exponential increase in surface
area, surface area to volume ratio, and effective stiffness, resulting in altered
physiochemical properties. Diverse categories of nanomaterials such as
nanoparticles, nanoporous scaffolds, nanopatterned surfaces, nanofibers, and
carbon nanotubes can be generated using advanced fabrication and processing
techniques. These materials are being increasingly incorporated in tissue
engineering scaffolds to facilitate the development of biomimetic substitutes to
replace damaged tissues and organs. Long-term success of nanomaterials in tissue
engineering is contingent upon the inflammatory responses they elicit in vivo.
This review seeks to summarize the recent developments in our understanding of
biochemical and biophysical attributes of nanomaterials and the inflammatory
responses they elicit, with a focus on strategies for nanomaterial design in
tissue engineering applications.
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