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2015 ; 15
(6
): 725-33
Nephropedia Template TP
Expert Rev Mol Diagn
2015[Jun]; 15
(6
): 725-33
PMID25936957
show ga
Exosomes have emerged as a promising biomarker. These vesicles abound in
biofluids and harbor molecular constituents from their parent cells, thereby
offering a minimally-invasive avenue for molecular analyses. Despite such
clinical potential, routine exosomal analysis, particularly the protein assay,
remains challenging, due to requirements for large sample volumes and extensive
processing. We have been developing miniaturized systems to facilitate clinical
exosome studies. These systems can be categorized into two components:
microfluidics for sample preparation and analytical tools for protein analyses.
In this report, we review a new assay platform, nano-plasmonic exosome, in which
sensing is based on surface plasmon resonance to achieve label-free exosome
detection. Looking forward, we also discuss some potential challenges and
improvements in exosome studies.