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10.5582/irdr.2015.01038

http://scihub22266oqcxt.onion/10.5582/irdr.2015.01038
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C4660865!4660865 !26668784
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suck abstract from ncbi


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pmid26668784
      Intractable+Rare+Dis+Res 2015 ; 4 (4 ): 214-6
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  • Nailfold capillaroscopic changes in Kindler syndrome #MMPMID26668784
  • Dobrev HP ; Vutova NI
  • Intractable Rare Dis Res 2015[Nov]; 4 (4 ): 214-6 PMID26668784 show ga
  • Kindler syndrome (KS), the fourth major type of hereditary epidermolysis bullosa (HEB), is a rare, autosomal recessive disorder characterized by skin fragility and blistering at birth followed by development of marked photosensitivity and progressive poikilodermatous skin changes in later years. We reported here the case of a 54-year-old woman, who fulfills the diagnostic criteria of KS type of HEB, putting accent on the nailfold capillaroscopic changes. Using videocapillaroscopy we observed pronounced alterations in finger nail capillaries including reduction in capillary density, features of neoangiogenesis (architectural derangement, elongated loops, extremely tortuous, bushy or branching capillaries, thin, branching and interconnected capillaries), enlarged and giant capillaries. We consider the changes observed as an adaptive mechanism that compensate the loss of capillaries due to chronic periungual trauma. Further studies with larger number of patients are needed to confirm the significance of capillaroscopy findings for patients with HEB.
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