NaNog: A pluripotency homeobox (master) molecule
#MMPMID26566529
Allouba MH
; ElGuindy AM
; Krishnamoorthy N
; Yacoub MH
; Aguib YE
Glob Cardiol Sci Pract
2015[]; 2015
(3
): 36
PMID26566529
show ga
One of the most intriguing aspects of cell biology is the state of pluripotency,
where the cell is capable of self-renewal for as many times as deemed
"necessary", then at a specified time can differentiate into any type of cell.
This fundamental process is required during organogenesis in foetal life and
importantly during tissue repair in health and disease. Pluripotency is very
tightly regulated, as any dysregulation can result in congenital defects,
inability to repair damage, or cancer. Fuelled by the relatively recent interest
in stem cell biology and tissue regeneration, the molecules implicated in
regulating pluripotency have been the subject of extensive research. One of the
important molecules involved in pluripotency, is NaNog, the subject of this
article.
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