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2017 ; 2017
(ä): 4817275
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NXP-2 Positive Dermatomyositis: A Unique Clinical Presentation
#MMPMID28695037
Butt Z
; Patel L
; Das MK
; Mecoli CA
; Ramji A
Case Rep Rheumatol
2017[]; 2017
(ä): 4817275
PMID28695037
show ga
Dermatomyositis (DM), a myopathy associated with inflammation and muscle
weakness, has historically been difficult to diagnose. Recently, nuclear matrix
protein (NXP-2) antibodies have been described as a myositis-specific antibody
that may aid in the diagnostic evaluation. We present the case of a 21-year-old,
previously healthy, African American male with DM. He presented to our outpatient
clinic with periorbital swelling and a rash, for which he was started on
prednisone by an ophthalmologist. Towards the end of the prednisone taper, he
began to experience muscle weakness, a worsening rash, and dysphagia to solids
with a resultant loss of 60 pounds within a month. He was transferred to a
tertiary care hospital where he was further evaluated and ultimately diagnosed
with dermatomyositis, supported by skin and muscle biopsies, and was found to be
positive for NXP-2. He was given intravenous immunoglobulin (IVIG) and high-dose
steroids with improvement.